PBME Topical™ — Pure Bone Marrow Exosomes

A purified exosome product isolated from living human bone marrow mesenchymal stem cells. Containing growth factors and exosomes for topical cosmetic applications.

Product Specifications

  • Product: PBME Topical™ — Pure Bone Marrow Exosomes
  • Directions: Topical use only
  • Contents: One 5 mL vial per box
  • Exosome Count: >50 billion exosomes per vial (>10 billion per mL)
  • Growth Factors: 1,000+ characterized regulatory proteins
  • Source: Living U.S. human bone marrow MSC donors
  • Processing: Proprietary cGMP manufacturing
  • Sterility: Sterile filtered and tested per USP<71>
  • Cleanroom: ISO 14644-1 Level 7
  • Particle Size: 70nm ± 6.2nm (within the 30–150nm exosome range) REF: PBME-001-5.0m
  • Classification: Cosmetic — topical use

What Are Exosomes?

Pure Bone Marrow Exosomes Topical. 

PBME Topical is a purified exosome product isolated from donated human mesenchymal stem cells (MSCs). Exosomes are extracellular vesicles that contain growth factor (GF) proteins along with mRNA and miRNA, they are acellular, do not contain DNA and are the communication mediators between cells.



PBME Topical exosomes are isolated from living bone marrow donors in the US that have been fully screened and characterized to assure purity, quality and integrity of the cells and exosomes. Future Medical Products isolates and purifies the exosomes from the cells using a proprietary process and series of patented technologies. This process ensures the protection of the 3D structure of these proteins and exosomes to ensure bioactivity over the life of the product. Each donor is screened to the highest FDA standards. Every lot tested for purity and sterility, and the exosome quantity is determined with an advanced nano-particle counter to ensure the consistency of each vial. Minimum requirements for every lot are 10 billion exosomes, containing +1,000 characterized GFs, mRNA + miRNA. If these requirements aren’t met the lot is not used for commercial distribution. Future Medical Products’ cell line is listed on a drug master file with the FDA and has a full assay test on viruses that the FDA signs off on. The Phenotypes and Genotypes of parents of the donor are also established.

1,000+ Regulatory Proteins Including:

NAME DESCRIPTION FUNCTION
VEGFR VEGF Receptor Angiogenesis
VEGF Vascular Endothelial Growth Factor Angiogenesis & Chemotaxis
Ang1 Angiopoietin Angiogenesis,Supports VEGF
TIMP-1 Collagenase Inhibitor Blocks matrix breakdown
TIMP-2 Collagenase Inhibitor Blocks matrix breakdown
IL-1B Interleukin 1B Cell Proliferation, Differentiation, Modulates Inflammation
PDGF-AA Platelet Derived Growth Factor Cell Survival & MSC Proliferation (Mitogenic)
TGFβ3 Transforming Growth Factor Beta 3 Immunology, Modulates Inflammation
bFGF Basic Fibroblast Growth Factor Mitogenic Cell Survival & Tissue Regeneration
HGF Hepatocyte Growth Factor Wound Healing, Tissue Regeneration & Organ Survival

Why Future Medical Products

Visual: A 3-step diagram or infographic illustrating the three concurrent pathways. Clean, scientific style

Modulate Inflammation

Growth factors and exosomes work to shift the treatment environment from a chronic inflammatory state to one that supports healing and regeneration.

Reprogram and Protect Existing Cells

Regenerate New Tissue

mRNA and miRNA carried by the exosomes deliver signals that promote new tissue formation and support the body’s natural regenerative capacity.

Comprehensive Safety Profile

Every lot of PBME Topical™ undergoes a full communicable disease testing panel and quality verification:

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  • Human Origin Material: Fresh Human Bone Marrow Aspirate
  • Source Country: United States of America
  • HIV Type I & II: NONREACTIVE
  • Hepatitis B (HBV): NONREACTIVE
  • Hepatitis C (HCV): NONREACTIVE
  • Treponema pallidum: NONREACTIVE
  • HTLV-I & HTLV-II: NONREACTIVE
  • Cytomegalovirus: NEGATIVE
  • West Nile virus: NONREACTIVE
  • Zika virus: NEGATIVE
  • Trypanosoma cruzi: NONREACTIVE
  • Processed in ISO 14644-1 Level 7 Cleanroom: PASSED
  • Particle Size (30–150nm): 70nm ± 6.2nm — PASSED
  • Particle Quantity (>10 billion exosomes/mL): PASSED
  • Sterility Test — USP<71> (SCD and FTM): NO GROWTH — PASSED


All donors are pre-COVID and determined to be free from risk factors for, and clinical evidence of, infection due to relevant communicable disease agents. All donors are tested by a CLIA-certified laboratory using approved test methods and deemed eligible according to 21 CFR 1271 Subpart C.


Visual: Particle size distribution graph (FTLA distribution chart from brochure) showing the 70nm peak.

Characterized Composition

  • 1,000+ characterized regulatory proteins including growth factors, cytokines, and chemokines
  • Contains mRNA and miRNA signaling molecules
  • Key proteins identified: VEGF, VEGFR, PDGF-AA, TGFβ3, bFGF, HGF, Ang1, IL-1B, TIMP-1, TIMP-2
  • Exosome count: >50 billion per vial (>10 billion per mL)
  • Particle size: 70nm ± 6.2nm (within the 30–150nm exosome range)
  • Acellular — does not contain DNA or whole cells
  • Each lot tested and characterized using advanced nano-particle counting
  • Full protein characterization report available upon request

How Is PBME Topical™ Applied?

PBME Topical™ is FDA approved for topical applications. Once thawed, draw the material from the vial into a syringe and apply the product directly onto the area of treatment. The product has been used by clinicians in the following applications:

Bring PBME Topical™ to Your Practice

Request pricing, ask a question, or schedule a peer-to-peer call with a KOL who uses PBME Topical™ in your specialty.

Request Pricing | Call (314) 481-9797